George Fromm

George Fromm

Company: Shattuck Labs

Job title: Vice President of Research & Development


Understanding How & Why LIGHT (TNFSF14) Co-Simulation Enhances Myeloid Cell Activation & Anti-Tumor Immunity in the Setting of PD-(L)1 & TIGIT Checkpoint Blockade 9:30 am

• Outlining how TIGIT-Fc-LIGHT was designed to block all TIGIT-ligand interactions, provide immune co-stimulation to CD8+ T and NK cells via HVEM and myeloid cells by LTBR • In combination with CPI, TIGIT-Fc-LIGHT may broaden anti-tumor responses into PDL1-low and CPI acquired resistance tumors • Addressing why TIGIT-Fc-LIGHT differs from antibody blockade of TIGIT, since…Read more

day: Day Two

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